Increased leukotriene C4 and vasogenic edema surrounding brain tumors in humans
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Increased leukotriene C4 and vasogenic edema surrounding brain tumors in humans.
Leukotrienes are pharmacologically active compounds that promote vascular permeability. In this study we sought to determine whether tissue leukotriene-like immunoreactivity was increased in intracranial tumors associated with peritumoral edema. In 20 patients undergoing craniotomy tissue specimens were immediately frozen after removal and tissue leukotriene C4 levels were determined by radioim...
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Brain edema (BE) research lacks quantitative regional methods. We modified the method of Pappius and McCann (1969), who used radioactive iodinated P serum albumin (R1SA) as a label for vasogenic BE fluid. To correct for intravascular plasma volume we used Cr^ labelled red blood cells and calculated equivalent extravascular plasma volume (EVPV). The modified RISA method was compared with a stand...
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The effects on eicosanoid levels were investigated in the stroke-resistant spontaneously hypertensive rat (SHRSR) brain and the relation of eicosanoid to the progression of cerebral edema was studied. The effects of dexamethasone, indomethacin and AA-861 on the induction of eicosanoids and cerebral edema were also studied in this model. Global cerebral ischemia was induced by occluding the bila...
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Figure 4. From left to right: maps of FA (from DTI), intracellular fraction, CSF fraction and ODI (from NODDI) in the same lesion shown in fig.3 NODDI performs better than DTI in brain tumors with vasogenic edema Matteo Figini, Giuseppe Baselli, Marco Riva, Lorenzo Bello, Hui Zhang, and Alberto Bizzi Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, MI, I...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 1986
ISSN: 0364-5134,1531-8249
DOI: 10.1002/ana.410190613